CAS number：630124-46-8 molecular formula：C26H30F3N7O2
Information AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor ofFlt3with ki of 0.12 μM.Besides FLT3, AST487 also inhibitsRET,KDR,c-KIT,and c-ABL kinasewith IC50 values below 1 μM. Targets RET ; KDR ; c-Kit ; c-Abl ; FLT3 (Cell-free assay) ; ;; 0.12 μM(Ki)
| Chinese alias | - | ||
| English alias | NVP-AST487 | NVP-AST-487 | AC-5620 | W34UO2M4T6 | HY-15002 | ZB1589 | BDBM31085 | 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea | DTXSID70212239 | Q27074554 | HY-W009498 | 1-[4-[(4-eth | ||
| CAS number | 630124-46-8 | molecular formula | C26H30F3N7O2 |
| molecular weight | 529.56 g/mol | Exact mass | - |
| PSA | 94.700 Ų | logp | 3.8 |
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