CAS number：1380575-43-8 molecular formula：C28H38Cl3N5O3S
Ceritinib dihydrochloride (LDK378 dihydrochloride) 是一种选择性，口服可生物利用且具有 ATP 竞争性的 ALK 酪氨酸激酶抑制剂，IC50 为 200 pM。Ceritinib dihydrochloride (LDK378 dihydrochloride) 还抑制 IGF-1R，InsR 和 STK22D，IC50 值分别为 8、7 和 23 nM。Ceritinib dihydrochloride (LDK378 dihydrochloride) 显示出良好的抗肿瘤效力。
| Chinese alias | 色瑞替尼二盐酸盐 | ||
| English alias | 5-Chloro-n2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 2HCl | Ceritinib dihydrochloride | LDK378 2HCl (Ceritinib) | UNII-08381UU98P | 2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfon | ||
| CAS number | 1380575-43-8 | molecular formula | C28H38Cl3N5O3S |
| molecular weight | 631.06 g/mol | Exact mass | ≥98% |
| PSA | 114.000 Ų | logp | 7.243 |
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