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Itacitinib (INCB39110)

CAS number：1334298-90-6    molecular formula：C26H23F4N9O

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overview

compound introduction

Itacitinib (INCB39110)是Janus-associated kinase 1 (JAK1)的抑制剂，具有口服生物活性和潜在的抗肿瘤活性。 Itacitinib 是一种选择性JAK1抑制剂，对 人JAK1的IC50值为 2 nM。它对JAK1选择性是 JAK2 的 20 倍多，是 JAK3 和 TYK2 的 100 倍多。 应用： 伊他替尼用于骨髓纤维化的研究。

Specs

Chinese alias-
English alias1334298-90-6 | Itacitinib (USAN/INN) | Itacitinib | BCP13794 | 1651228-00-0 | 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile | HY-W018392 | 19J3781LPM
CAS number1334298-90-6molecular formulaC26H23F4N9O
molecular weight553.51 g/molExact mass-
PSA120.000 Ųlogp1.6

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