Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay In Vitro Butyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells. Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34 + hematopoietic progenitor cellls. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Butyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34 + cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:JAK2 STAT3 STAT5
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Butyzamide
CAS number：1110767-45-7 molecular formula：C29H32Cl2N2O5S
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| Chinese alias | 丁酰胺 | ||
| English alias | - | ||
| CAS number | 1110767-45-7 | molecular formula | C29H32Cl2N2O5S |
| molecular weight | 591.55 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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