Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor ( TKI ) with IC 50 s of 6.7, 1.9 and In Vitro Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC 50 s of 6.7, 1.9 and In Vivo When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib Tosylate (CT053PTSA) potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues. In orthotopic U87MG human glioblastoma xenograft model, Ningetinib Tosylate prolongs the median survival time (MST) and yields significant increase in life-span value (ILS=32%, p=0.003) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:VEGFR2 1.9 nM (IC 50 )
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Ningetinib Tosylate
CAS number：1394820-77-9 molecular formula：C38H37FN4O8S
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| Chinese alias | 甲磺酸宁格替尼 | ||
| English alias | A903380 | MFCD28142839 | SB17297 | N-(3-Fluoro-4-((7-(2-hydroxy-2-methyl-propoxy)-4-quinolyl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-pyrazole-4-carboxamide, 4-methylbenzenesulfonic acid | R7I5725FES | UNII-R7I5725FES | HY-107145 | SCHEMBL12003816 | BN1684 | ||
| CAS number | 1394820-77-9 | molecular formula | C38H37FN4O8S |
| molecular weight | 728.8 g/mol | Exact mass | ≥99% |
| PSA | 167.000 Ų | logp | - |
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