D-myo-Inositol-2,4,5-triphosphate sodium salt

D-肌醇-2,4,5-三磷酸钠盐（通常称为IP3）是研究最多的InsP。IP3是细胞中由磷脂酶C（PLC）介导的磷脂酰肌醇-4,5-二磷酸水解产生的第二信使。Ins（1,4,5）P3与其在内质网上的受体的结合导致钙通道的开放和细胞内钙的增加。 The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(2,4,5)P3 is a metabolically stable analog of Ins(1,4,5)P3 that is commonly used to study Ca2+ signaling pathways. Ins(2,4,5)P3 acts as a partial agonist at rat hepatic IP3 receptors, exhibiting 65% of the maximal Ca2+ response obtained with Ins(1,4,5)P3.

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