Heat shock proteins (HSPs) are a family of highly conserved stress response proteins. Heat shock proteins function primarily as molecular chaperones by facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. HSPs are typically expressed at low levels under normal physiological conditions but are dramatically up-regulated in response to cellular stress. Elevated levels of HSPs have been observed in association with ischemia/reperfusion, cancer, and chronic heart failure. HSP27 is a member of the small heat shock protein family, which also includes HSP25 and the alpha-crystallins. HSP27 forms a large oligomer and the extent of phosphorylation plays a role in determining specific functions. HSP27 also functions as an anti-apoptotic molecule, regulating apoptosis through direct interaction with key components of the apoptotic pathway. HSP27 binds and sequesters cytochrome c released from the mitochondria in response to an apoptotic stimulus. This prevents the proper assembly of the apoptosome and subsequently, the activation of procaspase-9 and procaspase-3.
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Recombinant Human HSP27 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人HSP27蛋白 | 重组人 HSP27 蛋白 | ||
| English alias | 28 kDa heat shock protein | DKFZp586P1322 | Estrogen-regulated 24 kDa protein | Heat shock 27 kDa protein | heat shock 27kD protein 1 | heat shock 27kDa protein 1 | heat shock protein beta-1 | HMN2B | HS.76067 | HSP25 | HSP27 | HSP27HSP 27 | HSP28CMT2F | | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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