compound introduction
SB705498是一种hTRPV1拮抗剂，抑制TRPV1的Capsaicin，酸和热激活，IC50分别为3 nM， 0.1 nM和6 nM，该作用具有一定的电压依赖性，作用于TRPV1比作用于TRPM8选择性高100倍以上。Phase 2。
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SB705498
CAS number：501951-42-4 molecular formula：C17H16BrF3N4O
overview
Specs
| Chinese alias | - | ||
| English alias | (R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)urea | AC-32677 | HY-10633 | 1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)pyridin-2-yl]pyrrolidin-3-yl]urea | SCHEMBL1350298 | 3-acetamidophenyl- boronic acid | BDBM20504 | GTP | ||
| CAS number | 501951-42-4 | molecular formula | C17H16BrF3N4O |
| molecular weight | 429.23 g/mol | Exact mass | - |
| PSA | 57.300 Ų | logp | 3.8 |
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