Recombinant Human Oncostatin M/OSM Protein

Oncostatin M (OSM) is an approximately 30 KDa secreted cytokine belonging to the Interleukin-6 family. Like other members of the IL-6 family such as IL-11, CNTF, and Cardiotrophin-1, OSM plays crucial roles in inflammation, neuroprotection, hematopoiesis, metabolism, and development. The human OSM cDNA encodes a 252 amino acid (aa) prepro protein with a signal peptide and a hydrophilic C-terminal domain that are proteolytically processed to generate the 195 aa mature form. Although both mature and pro-OSM are equally active in radioreceptor assays, the mature OSM is 5 to 60 fold more active in growth inhibition assays. Thus, proteolytic processing of the pro-OSM peptide may be important in regulating the in vivo activities of OSM. Cytokines of the IL-6 family share a common receptor subunit, gp130, which allows intracellular signal transduction. In contrast to other cytokines, OSM binds gp130 with very low affinity and has little to no biological activity unless a second receptor chain is recruited. The OSM-gp130 complex recruits either LIF R alpha or OSM R beta to form the OSM receptor type I or OSM receptor type II, respectively. Among multiples roles, OSM has been reported to modulate tumor cell and epithelial cell growth. An axis involving OSM, CD40 Ligand, and OSM receptor described as an antiviral and immunostimulatory system is disrupted in patients with liver showing hepatitis C infection. Human OSM shares 45% aa sequence homology with mouse and rat OSM.

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