Fenbendazole-d 3 is a deuterium labeled Fenbendazole. Fenbendazole-d 3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53. In Vitro Fenbendazole-d3 (20 µM; for 48 h) reverses the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration. Fenbendazole-d3 (10 µM; for 48 h) elevates the protein expression levels of HIF-1α and GLUT1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: BT-549 and MCF-7 cells Concentration: 20 µM Incubation Time: For 48 h Result: Reversed the inhibiting influence exerted by miR-143-5p on proliferation, colony-forming capacity, and migration. Western Blot AnalysisCell Line: BT-549 and MCF-7 cells Concentration: 10 µM Incubation Time: For 48 h Result: Elevated the protein expression levels of HIF-1α and GLUT1. Form:Solid
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Fenbendazole-d3
CAS number：1228182-47-5 molecular formula：C15H10D3N3O2S
overview
compound introduction
Specs
| Chinese alias | 芬苯达唑-d3 | N-（5-苯硫基-1H-苯并咪唑-2-基）氨基甲酸三氘代甲基酯 | (6-(苯硫基)-1H-苯并[d]咪唑-2-基)氨基甲酸(甲基-d3)酯 | 甲基-d3 5-(苯硫基)-2-苯并咪唑氨基甲酸酯 | ||
| English alias | Fenbendazole-d3, VETRANAL(TM), analytical standard | Fenbendazole D3 (methyl D3) 100 microg/mL in Acetonitrile | F90888 | Fenbendazole-d3 | Trideuteriomethyl N-(5-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate; Trideuteriomethyl N-(6-phenylsulfanyl-1H-benz | ||
| CAS number | 1228182-47-5 | molecular formula | C15H10D3N3O2S |
| molecular weight | 302.37 g/mol | Exact mass | - |
| PSA | 92.300 Ų | logp | 3.600 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
1228182-47-5 | Fenbendazole-d3.pdf
