compound introduction
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) 是一种来自蜡菊 (Helichrysum Trilineatum) 的抗菌 (antibacterial) 化合物，具有抗诱变作用的酪氨酸酶抑制剂。Pinocembrin chalcone 促进 AMP 激活的蛋白激酶 (AMPK) 活化，改善葡萄糖耐受性，增加肌肉脂肪酸氧化 (FAO)，并在高脂饮食诱导的糖尿病小鼠中减少肝脏和骨骼肌中的脂肪积累。Pinocembrin chalcone 有望用于胃溃疡和糖尿病的研究。 Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound from Helichrysum Trilineatum. Pinocembrin chalcone facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle FAO and reduces fat accumulation in the liver and skeletal muscles in high-fat diet-induced (HFD) diabetic mice. Pinocembrin chalcone is promising for research of gastric ulcers and diabetes.
