compound introduction
H 89 2HCl是一种有效的PKA抑制剂，Ki为48 nM，作用于PKA比作用于PKG选择性高10倍，比作用于PKC， MLCK，钙调蛋白激酶II和酪蛋白激I/II选择性高500倍。 应用： H-89二盐酸盐水合物抑制蛋白激酶A，用于Leydig细胞、 原代颅骨成骨细胞（pOB）、大鼠颗粒细胞系（LH-15细胞）[3] 和人脐静脉内皮细胞（HUVEC）。 H 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II. Application： H-89 dihydrochloride hydrate inhibits protein kinase A, used in Leydig cells, primary cranial osteoblasts (POBs), rat granular cell line (LH-15 cells) [3], and human umbilical vein endothelial cells (HUVEC).
