compound introduction
XCT-790 (Compound 12) 是一种有效的、选择性的 estrogen-related receptor α (ERRα) 的反向激动剂，其IC50值为0.37 μM。XCT-790 (Compound 12) 对ERRγ和雌激素受体ERα和ERβ无活性。XCT-790 (Compound 12) 可显著地抑制体内肿瘤的生长和血管生成并诱导凋亡。 application： XCT790 has been used: as an estrogen-related receptor (ERR)α inverse agonist in C2C12 myotubes as an estrogen-related receptor (ERR)α inverse agonist to elucidate decidualization functionality of ERRα in endometrial embryonic stem cells as an autophagy inducer in human neuroblastoma SH-SY5Y and HeLa cell lines
