说明： SR-18292可有效抑制PGC-1α葡萄糖异生活性并通过调节GCN5和PGC-1α的相互作用来减少HNF4α的共激活。 Information SR-18292 SR-18292 inhibits PGC-1α gluconeogenic activity and reduces co-activation of HNF4α by modulating the interaction between GCN5 and PGC-1α. Targets PGC-1α In vitro SR-18292 is a potent inhibitor of the gluconeogenic gene expression and glucose production in hepatocytes. It increases the interaction of PGC-1α with GCN5 and reduces co-activation of HNF4α by PGC-1α. SR-18292 suppresses HNF4α/PGC-1α gluconeogenic transcriptional function. In vivo SR-18292 reduces blood glucose, strongly increases hepatic insulin sensitivity and improves glucose homeostasis in dietary and genetic mouse models of type 2 diabetes. SR-18292 suppresses hepatic glucose production and increases liver insulin sensitivity in vivo. The liver is a major target of SR-18292 and probably accounts for a significant part of its anti-diabetic effects. Cell Research(from reference) Cell lines：U-2 OS cells overexpressing Ad-GCN5 Concentrations：10 μM Incubation Time：18 h
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SR-18292
CAS number：2095432-55-4 molecular formula：C23H30N2O2
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| Chinese alias | - | ||
| English alias | 2-Propanol,1-[(1,1-dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)- | ||
| CAS number | 2095432-55-4 | molecular formula | C23H30N2O2 |
| molecular weight | 366.5 g/mol | Exact mass | 10mM in DMSO |
| PSA | 48.500 Ų | logp | 4.736 |
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