compound introduction
Poloppin 是一种有效的细胞渗透抑制剂，可抑制有丝分裂的 polo 样激酶 (PLK) (IC50=26.9 μM)，并可通过Polo-box 结构域 (PBD) 阻止蛋白之间的相互作用 (Kd= 29.5 μM)。Poloppin 选择性地杀死表达突变 KRAS 的细胞，增强有丝分裂中的死亡。Poloppin 可用作 KRAS 突变型癌症的研究，可作为单一试剂，或与 c-MET 抑制剂联合使用。
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Poloppin
CAS number：683808-78-8 molecular formula：C20H15BrF3NO2
overview
Specs
| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 683808-78-8 | molecular formula | C20H15BrF3NO2 |
| molecular weight | 438.24 g/mol | Exact mass | - |
| PSA | 42.200 Ų | logp | 5.400 |
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