cholest-(25R)-5-ene-3β,27-diol

27-羟基胆固醇（27-HC）是由胆固醇在肝脏中的甾醇27-羟化酶作用下合成的。在0.15至0.73 μM的循环范围中，它是一种丰富的氧化甾醇。27-HC是胆汁合成的底物 应用： 观察其对肝脏脂质积累的抑制作用；作为乳腺癌细胞系中的肝X受体(LXR)配体；作为液相色谱-串联质谱(LC-MS-MS)法中的对照，量化空肠样品中的25-OHC 27-hydroxycholesterol (27-HC) is synthesized by cholesterol under the action of sterol 27-hydroxylase in the liver. It is an abundant oxidizing sterol in the cyclic range of 0.15 to 0.73 μM. 27-HC is a substrate for bile synthesis Product description： 27-Hydroxycholesterol, an oxysterol secreted from macrophages, has been shown to be capable of passing through the blood-brain barrier and entering the circulation via the brain. This compound has been shown to be a cholesterol oxidation metabolite that causes an increase in levels of GADD 153 and caspase-12 in ARPE-19 cells in vitro. 27-Hydroxycholesterol has also been reported to increase levels of Aβ peptide production, reduce mitochondrial membrane potential, and induce nuclear factor κB (NFκB) and heme-oxygenase 1 (HO-1). Overall, 27-Hydroxycholesterol displays apoptotic properties via reactive oxygen species (ROS) generation, glutathione depletion, and inflammation. 27-Hydroxycholesterol is an activator of LXR α and LXR β. An oxysterol with cholesterol oxidation metabolite properties. Application： To observe its inhibitory effect on lipid accumulation in liver. As a liver X receptor (LXR) ligand in breast cancer cell lines; As a control in liquid chromatography-tandem mass spectrometry (LC-MS-MS), 25-OHC in jejunum samples was quantified

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