Purity:>95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162, PubMed:33854235). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162). Hypophosphorylates RB1 in early G1 phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1833066, PubMed:1827756, PubMed:8302605, PubMed:19412162). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529).
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Recombinant Human Cyclin D1 Protein
CAS number：unknown molecular formula：
overview
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Specs
| Chinese alias | 重组人Cyclin D1蛋白 | 重组人类细胞周期蛋白D1蛋白 | ||
| English alias | AI327039 | B cell CLL/lymphoma 1 | B cell leukemia 1 | B cell lymphoma 1 protein | B-cell lymphoma 1 protein | BCL 1 | BCL-1 | BCL-1 oncogene | BCL1 | BCL1 oncogene | ccnd1 | CCND1/FSTL3 fusion gene | CCND1/FSTL3 fusion gene, included | CCND1/IGHG1 fusion | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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