PDPH(3-(2-pyridyldithio)propionyl hydrazide)

Product introduction： PDPH is a short, pyridyldithiol-and-hydrazide crosslinker for reversibly conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates). Features of PDPH : • Reactive groups :pyridyldisulfide andhydrazide • Reactive toward : sulfhydryl groups and carbonyl (aldehyde) groups • Short (9.2A), sulfhydryl-to-aldehyde crosslinker with disulfide bond spacer arm (cleavable) • Pyridyldithiol group results in attachment to sulfhydryls via disulfide bond, which can be cleaved with DTT, TCEP or other reducing agents • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates • Usesodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups • Use withEDC to conjugate primary amine of hydrazide group to carboxyl groups Product References: Crosslinker Application Guide -- search for recent literature references for this product • Reactive Moiety: Hydrazide,Pyridyldisulfide • Crosslinker Type: Heterobifunctional • Form: Powder: • Spacer: Short( Labeling Method: Chemical Labeling • Spacer Arm Length: 9.2 Å

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