Mal-Val-Ala-PAB-N(SO2Me)-Exatecan (Compound LE14) 是 ADC 毒素 Exatecan 和连接子 Mal-Val-Ala-PAB-N(SO2Me) 的偶联物。Mal-Val-Ala-PAB-N(SO2Me)-Exatecan 可用于合成 ADC FZ-AD005。FZ-AD005 是一种靶向 delta 样配体 3 (DLL3, KD=58.3 pM) 的 ADC，对 SCLC 癌症具有抗肿瘤活性。 体外研究： ADC 由一种抗体组成，ADC 细胞毒素通过 ADC 接头连接到该抗体上。 Mal Val Ala PAB-N (SO2Me) - Exatecan (Compound LE14) is a conjugate of ADC toxin Exatecan and linker Mal Val Ala PAB-N (SO2Me). Mal Val-Ala-PAB-N (SO2Me) - Hexatecan can be used to synthesize ADC FZ-AD005. FZ-AD005 is an ADC targeting delta like ligand 3 (DLL3, KD=58.3 pM) with anti-tumor activity against SCLC cancer. In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) In vitro studies: ADC is composed of an antibody, and ADC cytotoxin is connected to the antibody through an ADC adapter.
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Mal-Val-Ala-PAB-N(SO2Me)-Exatecan
CAS number：2575682-08-3 molecular formula：C56H65FN8O15S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2575682-08-3 | molecular formula | C56H65FN8O15S |
| molecular weight | 1141.22 g/mol | Exact mass | ≥96% |
| PSA | - | logp | - |
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