MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC) In Vitro In MC-GGFG-Exatecan, GGFG is selectively cleaved by lysosomal enzymes (presumably cathepsins). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In MC-GGFG-Exatecan, GGFG is known to release drugs into tumor tissue without releasing them into peripheral circulation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Camptothecins
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MC-GGFG-Exatecan
CAS number：1600418-29-8 molecular formula：C49H51FN8O11
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| Chinese alias | MC-GGFG-依沙替康 | ||
| English alias | - | ||
| CAS number | 1600418-29-8 | molecular formula | C49H51FN8O11 |
| molecular weight | 946.97 g/mol | Exact mass | ≥99% |
| PSA | 263.000 Ų | logp | 0.300 |
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