DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component In Vitro DC0-NH2 (0-3 nM; 72 hours) is highly potent against Ramos, Namalwa, and HL60/s cells with IC 50 values in the 1 pM to 10 pM range, and has 100 pM range when tested on COLO 205 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Ramos, Namalwa, HL60/s, and COLO 205 Cancer Cells Concentration: 0-3 nM Incubation Time: 72 hours Result: Inhibited Namalwa and HL60/s cells with IC 50 s of 7 and 30 pM, respectively. Form:Solid IC50& Target:Duocarmycins
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DC0-NH2
CAS number：615538-51-7 molecular formula：C31H24ClN5O3
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| Chinese alias | 氨气 | ||
| English alias | - | ||
| CAS number | 615538-51-7 | molecular formula | C31H24ClN5O3 |
| molecular weight | 550.01 g/mol | Exact mass | ≥95% |
| PSA | - | logp | - |
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