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2,5-Pyrrolidinedione, 1-[(5-azido-1-oxopentyl)oxy]-

CAS number:478801-48-8    molecular formula:C9H12N4O4

overview

compound introduction

N3-C4-NHS ester 是一种不可降解 (non-cleavable) 的ADC linker,可用于合成抗体偶联活性分子 (ADCs)。N3-C4-NHS ester 是一种点击化学试剂。它含有 Azide 基团,可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应(CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

Specs

Chinese alias-
English alias-
CAS number478801-48-8molecular formulaC9H12N4O4
molecular weight240.220 g/molExact mass≥99%
PSA78.000 Ųlogp0.800

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