compound introduction
5（S）-HPETE是由花生四烯酸和白三烯的生物合成前体的5-脂氧合酶代谢产生的单氢过氧多不饱和脂肪酸。描述了5（S）-HPETE在TA1细胞中不诱导c-jun的情况下诱导c-fos，这表明TNF对c-fos的诱导可能是由HPETE介导的。还描述了5（S）-HPETE调节人嗜碱细胞的组胺释放。 5(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by 5-lipoxygenase metabolism of arachidonic acid and a biosynthetic precursor to leukotrienes. 5(S)-HPETE is described to induce c-fos without inducing c-jun in TA1 cells, suggesting that c-fos induction by TNF may be HPETE-mediated. 5(S)-HPETE is also described to modulate histamine release from human basophils.
