compound introduction
9（R）-HODE是亚油酸的几种单羟基化产物之一。所有已知的哺乳动物脂加氧酶似乎都催化花生四烯酸和亚油酸的氧化，从而在氧的插入位置产生严格具有（S）构型的产物。然而，当与亚油酸一起温育时，人脐静脉内皮细胞和牛主动脉内皮细胞均显示产生9（R）-HODE。尚未确定9（R）-HODE的生理功能和催化其形成的酶。 9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) configuration at the site of oxygen insertion. However, both human umbilical vein endothelial cells and bovine aorta endothelial cells have been shown to yield 9(R)-HODE when incubated with linoleic acid. The physiological function of 9(R)-HODE and the enzyme that catalyzes its formation have not been determined.
