CAS number：870554-67-9 molecular formula：C19H16BrNO3S
GQ-16 是 PPARγ 的中等亲和力配体，Ki 值为 160 nM。GQ-16 有效抑制 Cdk5 介导的 PPARγ 磷酸化。GQ-16 也是 PPARγ 的部分激动剂，可减少脂肪生成。GQ-16 促进胰岛素增敏作用而不会增加体重。 GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. GQ-16 is an effective inhibitor of Cdk5-mediated phosphorylation of PPARγ. GQ-16 is a partial agonist of PPARγ with reduced adipogenic actions. GQ-16 promotes insulin Sensitization without weight gain.
| Chinese alias | - | ||
| English alias | 5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione | ||
| CAS number | 870554-67-9 | molecular formula | C19H16BrNO3S |
| molecular weight | 418.30 g/mol | Exact mass | - |
| PSA | 71.900 Ų | logp | 4.900 |
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