吡格列酮-d4是标记的噻唑烷二酮，可激活PPARγ，并在较小程度上激活PPARα。研究表明，吡格列酮-d4可增加NIIDM的内脏和外周葡萄糖摄取。已知吡格列酮-d4调节胰岛素敏感性基因，其控制多种组织例如肌肉细胞，脂肪组织和肝脏中的葡萄糖和脂质代谢。替代研究表明，吡格列酮d4激活Akt，同时上调cPLA2和Cox-2。吡格列酮-d4可有效干扰雄性颗粒细胞中芳香酶上的雄激素结合，从而抑制雌激素合成。 Pioglitazone-d4 is a labeled thiazolidinedione, which activates PPARγ and to a lesser extent PPARα. Studies show that Pioglitazone-d4 increases splanchnic and peripheral glucose uptake in NIIDM. It is known that Pioglitazone-d4 modulates insulin-sensitive genes which control glucose and lipid metabolism in a variety of tissues such as muscle cells, adipose tissue and the liver. Alternate studies show that Pioglitazone-d4 activates Akt, while upregulating cPLA2 and Cox-2. Pioglitazone-d4 is effective in interfering with androgen binding on aromatase in human granulosa cells, which inhibits estrogen synthesis.
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Pioglitazone-d4 (major)
CAS number：1134163-31-7 molecular formula：C19H16D4N2O3S
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| Chinese alias | 吡格列酮-d4(主要) | ||
| English alias | AD-4833-d4 | DTXSID90649422 | 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy-d4]phenyl]methyl]-2,4-thiazolidinedione | Pioglitazone-d4 (major) | 111025-46-8 (unlabeled) | 5-[[4-[1,1,2,2-tetradeuterio-2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4 | ||
| CAS number | 1134163-31-7 | molecular formula | C19H16D4N2O3S |
| molecular weight | 360.46 g/mol | Exact mass | ≥97% |
| PSA | - | logp | - |
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