CAS number：1534358-79-6 molecular formula：C25H25NO5
COH000 是共价的、不可逆的泛素样激活酶1 (E1) 的变构抑制剂，体外测得对 SUMO 化修饰的 IC50 值为 0.2 μM。 COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro。
| Chinese alias | - | ||
| English alias | 7-Oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid,1-[(1R)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-,2,3-dimethyl ester,(1R,4S)- | (1R,4S)-Dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2, | ||
| CAS number | 1534358-79-6 | molecular formula | C25H25NO5 |
| molecular weight | 419.47 g/mol | Exact mass | ≥96% |
| PSA | 73.900 Ų | logp | 4.000 |
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