Information JHU-083 JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b + cells and prevents depression-associated behaviors induced by chronic social defeat stress. Solutions are best fresh-prepared. Targets Glutaminase In vitro JHU-083 selectively inhibits T-cell proliferation and decreases T-cell activation, with no effect on DCs. In vivo orally administered JHU-083 significantly decreases the experimental autoimmune encephalomyelitis(EAE) severity in both prevention and treatment paradigms and reverses EAE-induced cognitive impairment. Cell Research(from reference) Cell lines：CD4 + T cells Concentrations：1 μM, 3 μM, 10 μM, 30 μM, or 100 μM Incubation Time：72h
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JHU-083
CAS number：1998725-11-3 molecular formula：C14H24N4O4
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| Chinese alias | - | ||
| English alias | Ethyl 2-(2-Amino-4-methylpentanamido)-DONL-Norleucine,L-leucyl-6-diazo-5-oxo-,ethyl ester | ||
| CAS number | 1998725-11-3 | molecular formula | C14H24N4O4 |
| molecular weight | 312.36 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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