OSMI-4 是一种低纳摩尔的O-连接的N-乙酰半乳糖胺转移酶 (OGT) 的抑制剂，其在细胞中的EC50 值为3 μM。 产品应用： OSMI-4 是一种 O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) 的抑制剂，在细胞中的EC50值为3 μM。 Information OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells. Targets OGT (Cell-free assay) 3 μM(EC50) In vitro OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology. Cell Research(from reference) Cell lines：HEK293T cells Concentrations：5 μM, 10 μM, 20 μM Incubation Time：2 h, 8 h, 16 h, 24 h
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OSMI-4
CAS number：2260791-14-6 molecular formula：C27H26ClN3O7S2
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| Chinese alias | - | ||
| English alias | ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate | ||
| CAS number | 2260791-14-6 | molecular formula | C27H26ClN3O7S2 |
| molecular weight | 604.09 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | 3.175 |
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