Information IACS-13909 IACS-13909 (BBP-398) is a specific and potent allosteric inhibitor of SHP2 (Src homology 2 domain-containing phosphatase) that suppresses signaling through the MAPK pathway. Targets SHP2 In vitro IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses signaling through the MAPK pathway. IACS-13909 potently impedes proliferation of tumors harboring a broad spectrum of activated RTKs as the oncogenic driver. IACS-13909 potently suppresses tumor cell proliferation in vitro. In vivo In EGFR-mutant osimertinib-resistant NSCLC models with EGFR-dependent and EGFR-independent resistance mechanisms, IACS-13909, administered as a single agent or in combination with osimertinib, causes tumor regression in vivo. Cell Research(from reference) Cell lines：KYSE-520 cells Concentrations：0-10000 nM Incubation Time：2 h
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IACS-13909
CAS number：2160546-07-4 molecular formula：C17H18Cl2N6
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| Chinese alias | - | ||
| English alias | BBP-3984-Piperidinamine,1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methyl- | ||
| CAS number | 2160546-07-4 | molecular formula | C17H18Cl2N6 |
| molecular weight | 377.27 g/mol | Exact mass | 10mM in DMSO |
| PSA | 83.700 Ų | logp | 3.125 |
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