Information ML355 ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases. Targets 12-LOX In vitro ML355 displays nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In vivo In vivo PK studies where ML355 is administered as a solution via IV (3mpk) and PO (30mpk) demonstrated that ML355 is orally bioavailable (%F = 20) with good half-life (T1/2 = 2.9 hours). At 30 mpk dosing, ML355 achieves a Cmax of over 135 times the in vitro IC50 and remains over IC50 value for over 12 hours. The compound has low clearance (3.4 mL/min/kg) and good overall exposure (AUCinf) of 38 µM. Although, the volume of distribution (VD) observed is low (0.55 L/kg), the rest of the PK profiling results suggest a reasonable distribution between tissue and blood.
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ML355
CAS number：1532593-30-8 molecular formula：C21H19N3O4S2
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| Chinese alias | - | ||
| English alias | UNII-JKU4XCC48Y | NCGC00263773-01 | ML 355 | N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide | EX-A1987 | ML355 | ML-355 | AC-36858 | ML355 free base | VLX 1005 | SCHEMBL16646023 | ZR5 | HY-12341 | s6557 | N-2-B | ||
| CAS number | 1532593-30-8 | molecular formula | C21H19N3O4S2 |
| molecular weight | 441.52 g/mol | Exact mass | - |
| PSA | 137.000 Ų | logp | 4.077 |
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