9-PAHSA

9-PAHSA由与硬脂酸相连的棕榈酸组成，属于被称为羟基脂肪酸脂肪酸酯（FAHFAs）的支链脂质类。在胰岛素敏感小鼠的血清和白色脂肪组织中发现9-PAHSA的水平增加。胰岛素抵抗者的白色脂肪组织中的水平较低。对肥胖、糖尿病小鼠口服9-PAHSA的研究表明，葡萄糖耐量有所改善。在表征其机制时，发现9-PAHSA刺激胰岛素和GLP-1分泌，并通过激活GPR-120增强葡萄糖转运和Glut4转运蛋白。9-PAHSA也被证明具有抗炎特性。 Description Palmitic-acid-9-hydroxy-stearic-acid (9-PAHSA) is an isomeric form of bioactive fatty acid ester of hydroxyl-fatty acid (FAHFA).9-PAHSA is composed of palmitic acid attached to stearic acid and is in the class of branched lipids referred to as fatty acid esters of hydroxy fatty acids (FAHFAs). 9-PAHSA was found at increased levels in serum and white adipose tissue of insulin-sensitive mice. Levels were found to be lower in white adipose tissue of insulin-resistant humans. Studies of oral administration of 9-PAHSA to obese, diabetic mice showed improved glucose tolerance. In characterizing the mechanism, it was found that 9-PAHSA stimulates insulin and GLP-1 secretion and also enhances glucose transport and the Glut4 transporter through activation of GPR-120. 9-PAHSA was also shown to haveanti-inflammatory properties.

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