compound introduction
AZD8329 是一种有效的 11β-羟甾类脱氢酶 1 型 (11β-HSD1) 抑制剂，对人11β-HSD1 的IC50 值为 9 nM，与 11β-HSD2、17β-HSD1、17β-HSD3 相比，表现出良好的选择性。 AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC 50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3 In Vitro AZD8329 shows IC 50 s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 9 nM (Human 11β-HSD1)
