Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor ( PPAR ) agonist with predominant PPARα and moderate PPARγ activity with EC 50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. In Vivo In db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED 50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose. A 90-day repeated dose comparative study in Wistar rats and marmosets confirms efficacy (TG lowering) potential of Saroglitazar and has indicated low risk of PPAR-associated side effects in humans. Based on efficacy and safety profile, Saroglitazar appears to have good potential as novel therapeutic agent for treatment of dyslipidemia and diabetes . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PPARα 0.65 pM (EC 50 , HepG2 cell) PPARγ 3 nM (EC 50 , HepG2 cell)
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Saroglitazar magnesium
CAS number：1639792-20-3 molecular formula：C50H56MgN2O8S2
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| Chinese alias | 沙格列扎镁 | ||
| English alias | K8V5DLS63R | 1639792-20-3 | Q27282102 | EX-A5519 | MAGNESIUM, BIS((.ALPHA.S)-.ALPHA.-(ETHOXY-.KAPPA.O)-4-(2-(2-METHYL-5-(4-(METHYLTHIO)PHENYL)-1H-PYRROL-1-YL)ETHOXY)BENZENEPROPANOATO-.KAPPA.O)-, (T-4)- | Saroglitazar magnesium | magnesium;(2S)-2-ethoxy-3- | ||
| CAS number | 1639792-20-3 | molecular formula | C50H56MgN2O8S2 |
| molecular weight | 901.42 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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