RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo. In Vivo RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model . RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng•h/mL at 1 mg/kg, po) . RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice . Dosage: 30 mg/kg. Administration: Orally twice: at 30 min before and 8 h after IL-23 administration. Result: Inhibited the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose. Form:Solid
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RORγt Inverse agonist 6
CAS number：1887161-80-9 molecular formula：C28H29ClN6O5
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| Chinese alias | RORγt 反向激动剂 6 | ||
| English alias | - | ||
| CAS number | 1887161-80-9 | molecular formula | C28H29ClN6O5 |
| molecular weight | 565.02 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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