Taraxerone is isolated from Sedum sarmentosum . Taraxerone enhances effects on alcohol dehydrogenase ( ADH ) and acetaldehyde dehydrogenase ( ALDH ) activities with EC 50 values of 512.42 and 500.16 μM, respectively In Vivo Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure . Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 512.42 μM (ADH),500.16 μM (ALDH)
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Taraxerone
CAS number：514-07-8 molecular formula：C30H48O
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Specs
| Chinese alias | 蒲公英酮 | ||
| English alias | 3(2H)-PICENONE, 1,4,4A,5,6,6A,8,8A,9,10,11,12,12A,12B,13,14,14A,14B-OCTADECAHYDRO-4,4,6A,8A,11,11,12B,14B-OCTAMETHYL-, (4AR-(4Aalpha,6Abeta,8Abeta,12Abeta,12Balpha,14Aalpha,14Bbeta))- | MS-27476 | D-Friedoolean-14-en-3-one | 4,4,6a,8a,11,11,12b,14b-Octame | ||
| CAS number | 514-07-8 | molecular formula | C30H48O |
| molecular weight | 424.70 g/mol | Exact mass | ≥98% |
| PSA | 17.100 Ų | logp | 9.000 |
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