PKM2 activator 2 is a pyruvate kinase M2 ( PKM2 ) activitor with an AC 50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells In Vitro PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines. PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC 50 value of 66 nM in the luciferase-coupled assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PKM2 66 nM (EC 50 )
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PKM2 activator 2
CAS number：1186660-06-9 molecular formula：C20H18F2N2O4S2
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| Chinese alias | PKM2 激活剂 2 | ||
| English alias | - | ||
| CAS number | 1186660-06-9 | molecular formula | C20H18F2N2O4S2 |
| molecular weight | 452.49 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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