4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research. In Vitro 4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity. 4-O-Methyl honokiol (20 μM) increases the expression, transcription and DNA binding activities, and nuclear translocation of PPARγ in both in prostate PC-3 and LNCap cells. 4-O-Methyl honokiol (0-30 μM) inhibits LNCaP and PC-3 cancer cells growth, causes G0/G1 phase arrest and induces apoptotic cell death, and such effects can be reversed by PPARγ antagonist. 4-O-Methyl honokiol inhibits NF-κB activity and cancer cell growth, but such effects as well as its activation of PPARγ can be abolished by knock-down of p21. 4-O-methylhonokiol (0.5, 1 and 2 μM) reduces LPS-induced release of NO, PGE2, ROS, TNF-α and IL-1β in cultured astrocytes, and amyloidogenesis in cultured astrocytes and microglial BV-2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 4-O-Methyl honokiol (40 or 80 mg/kg, i.p. everyday for 4 weeks) inhibits the growth of SW620 and PC3 tumours in SW620 and PC3 xenograft model. 4-O-Methyl honokiol significantly increases the expression of p21 and PPARγ in the tumour tissues . 4-O-Methyl honokiol (0.5 or 1 mg/kg/day daily for 3 weeks) significantly ameliorates LPS-induced memory impairment, and inhibits LPS-induced iNOS and COX-2 expression in mice. 4-O-Methyl honokiol also shows inhibitory activities against the Aβ 1-42 accumulation, and activates astrocytes and microglia in LPS-injected mice brain. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Viscous liquid IC50& Target:PPARγ NF-κB
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4-O-Methyl honokiol
CAS number：68592-15-4 molecular formula：C19H20O2
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| Chinese alias | 4-O-甲基和厚朴酚 | ||
| English alias | Magreth-14a | 4'-O-Methylhonokiol | 4-O-Methylhonokiol | DTXSID50218693 | HY-U00450 | (1,1'-Biphenyl)-2-ol, 4'-methoxy-3',5-di-2-propenyl- | AMY20701 | UNII-TUH6B83HJW | 5,3''-Diallyl-4''-methoxy-biphenyl-2-ol | AC-34332 | METHYLHONOKIOL | F3098-0374 | [1 | ||
| CAS number | 68592-15-4 | molecular formula | C19H20O2 |
| molecular weight | 280.36 g/mol | Exact mass | ≥99% |
| PSA | 29.500 Ų | logp | 5.300 |
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