compound introduction
BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC 50 of 0.17 nM In Vitro BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC 50 of 3.4 nM. BAY-4931 only inhibits CYP2C8 in CYP inhibition test. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: UM-UC-9 cells Concentration: 0-10 μM Incubation Time: 7 days Result: Inhibited proliferation with an IC 50 of 3.4 nM. Form:Solid IC50& Target:PPAR-γ 0.17 nM (IC 50 , RT112-FABP4-NLucP cellular reporter assay) mouse PPARγ 0.14 nM (IC 50 , GAL4-NHR-LBD one hybrid reporter assay ) hPPARγ 0.40 nM (IC 50 , GAL4-NHR-LBD one hybrid reporter assay )
