cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING) , which activates a signaling cascade leading to the production of type I interferons and other immune mediators In Vitro cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice. ? cGAMP disodium directly activates murine and human dendritic cells in vitro. ? On stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF). ? cGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs . MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female C57BL/6 (H-2b) mice 6-8 weeks oldDosage: 5 µg Administration: Nostril mucosal adjuvant Result: Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. Form:Solid IC50& Target:Human Endogenous Metabolite
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cGAMP disodium
CAS number：2407516-83-8 molecular formula：C20H22N10Na2O13P2
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| Chinese alias | cGAMP二钠 | ||
| English alias | - | ||
| CAS number | 2407516-83-8 | molecular formula | C20H22N10Na2O13P2 |
| molecular weight | 718.37 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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