Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol bio In Vitro:Larsucosterol (DUR-928; 0-25 μM; 8 h; HepG2 cells) trimethylamine inhibits cholesterol biosynthesis by decreasing HMG-CoA reductase mRNA levels and decreases free [ 14 C] cholesterol in a dose-dependent manner. Larsucosterol (0-25 μM; 6 h; HepG2 cell In Vivo:Larsucosterol (DUR-928; 25mg/kg; i.p.; twice in 14 hours; C57BL/6J mice with nonalcoholic fatty liver diseases (NAFLD) model) trimethylamine reduces serum lipid levels in mice fed a high-fat diet. Larsucosterol (25mg/kg; i.p.; twice in 14 hours; C5 Biological Activity:Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol bio
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Larsucosterol (trimethylamine)
CAS number：unknown molecular formula：C30H46O5S.0.45C3H9N
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| Chinese alias | 拉苏克斯特醇(三甲胺) | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C30H46O5S.0.45C3H9N |
| molecular weight | 509.32 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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