CAS number：951395-08-7 molecular formula：C21H24Cl2N2O8
Tafamidis meglumine (Fx-1006A) 是一种有效、选择性的 transthyretin (TTR) 稳定剂，对野生型 WT-TTR 和突变型同源四聚体 V30M-TTR，V122I-TTR 的活性相当，EC50 值为 2.7-3.2 μM。Tafamidis meglumine 抑制淀粉样蛋白的生成。 Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis
| Chinese alias | 他发米帝司甲葡胺 | 氯苯唑酸甲葡胺盐 | 氯苯那敏葡甲胺 | ||
| English alias | Tafamidis meglumine | Vyndaqel | (2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylate | Fx 1006A | Fx1006A | Fx-1006A | UNII-ZU7CF08A1A | CHEBI:79345 | ||
| CAS number | 951395-08-7 | molecular formula | C21H24Cl2N2O8 |
| molecular weight | 503.33 g/mol | Exact mass | ≥99% |
| PSA | 177.000 Ų | logp | - |
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