Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy . In Vitro Inotersen sodium (0.16-20 μM; 16 h) dose-dependently reduces TTR mRNA levels in HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Inotersen sodium (10-100 mg/kg; s.c. twice a week for 4 weeks) reduces the plasma TTR protein by >80% in transgenic mice bearing the Ile84Ser human TTR mutant . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Inotersen sodium
CAS number：1432726-13-0 molecular formula：
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| Chinese alias | 伊诺特生钠 | ||
| English alias | - | ||
| CAS number | 1432726-13-0 | molecular formula | |
| molecular weight | 7601.00 g/mol | Exact mass | ≥93% |
| PSA | - | logp | - |
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