LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ 35 S]GTPγS binding with EC 50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research. In Vivo LY487379 (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage . LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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LY487379
CAS number：353231-17-1 molecular formula：C21H19F3N2O4S
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| Chinese alias | - | ||
| English alias | 4-MPPTS | N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine | BDBM50130608 | FT-0715485 | Q6460434 | A822730 | MS-28219 | DTXSID10431366 | HY-122255 | 2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)e | ||
| CAS number | 353231-17-1 | molecular formula | C21H19F3N2O4S |
| molecular weight | 452.45 g/mol | Exact mass | ≥98% |
| PSA | 77.100 Ų | logp | 4.100 |
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