CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD). In Vivo CX 717 (CX717; 20 mg/kg) has a rapid (30 min) but short-lasting (up to 24 h) antidepressantlike effect in the forced swim test.CX 717 also produces a rapid (up to 1 h) increase of brain-derived neurotrophic factor (BDNF) and a more sustained (up to 6 h) increase of p11. Intra-cortical infusion of CX 717 (85 mM) increases the efflux of noradrenaline, dopamine, and serotonin, but not glutamate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats weighing 280-350 gDosage: 20 mg/kg (administered at 1 mL/kg) Administration: Intraperitoneal (i.p.) injection Result: Evoked antidepressant-like effects (20 mg/kg, i.p.) did not alter the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and glutamate in the medial prefrontal cortex (mPFC). Form:Solid
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CX 717
CAS number：867276-98-0 molecular formula：C11H11N3O3
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| Chinese alias | - | ||
| English alias | 2,1,3-Benzoxadiazol-5-yl-4-morpholinylmethanone | 2,1,3-benzoxadiazol-5-yl(morpholin-4-yl)methanone | CX 717 | CX 717 (pharmaceutical) | EX-A6414 | SCHEMBL243542 | DB05047 | starbld0003244 | AKOS040758937 | DTXSID301241632 | Benzo[c][1,2,5]oxadiazol-5-yl( | ||
| CAS number | 867276-98-0 | molecular formula | C11H11N3O3 |
| molecular weight | 233.22 g/mol | Exact mass | ≥99% |
| PSA | 68.500 Ų | logp | 0.300 |
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