Talatisamine 是一种乌头生物碱，是一种特异性 K+ 通道阻滞剂。Talatisamine 能减弱 beta- 淀粉样低聚物对培养的皮层神经元的神经毒性。 Information Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities. Targets IK channel 146 μM In vitro Talatisamine is a specific blocker for I K channel. External application of talatisamine reversibly inhibited the delayed rectifier K+ current (IK) with an IC50 value of 146.0±5.8 μM in a voltage-dependent manner, but exhibited very slight blocking effect on the voltage-gated Na+ and Ca2+ currents even at the high concentration of 1-3 mM in rat hippocampal neurons. Talatisamine had no allosteric action on IK channel and was a pure blocker binding to the external pore entry of the channel.
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Talatisamine
CAS number：20501-56-8 molecular formula：C24H39NO5
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| Chinese alias | 塔拉乌头胺 | 塔拉萨敏 | ||
| English alias | FT-0775522 | Oprea1_414489 | NSC624752 | Aconitane-8,14-diol, 20-ethyl-1,16-dimethoxy-4-(methoxymethyl)-, (1-alpha,14-alpha,16-beta)- | Talatisamine | Talatizamine | 20-Ethyl-1,16-dimethoxy-4-(methoxymethyl)aconitane-8,14-diol | 20-Ethyl-1-alpha,16-beta-d | ||
| CAS number | 20501-56-8 | molecular formula | C24H39NO5 |
| molecular weight | 421.57 g/mol | Exact mass | ≥98% |
| PSA | 71.400 Ų | logp | -0.324 |
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