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RepSox

Dangerous Goods

CAS number：446859-33-2    molecular formula：C17H13N5

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overview

compound introduction

RepSox 是一种有效的选择性的 TGFβR-1/ALK5 抑制剂，抑制ALK5 自磷酸化，IC50 为 4 nM。An ATP-competitive inhibitor of TGF-β RI kinase RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively. An ATP-competitive inhibitor of TGF-β RI kinase

Specs

Chinese alias-
English aliasALK5 Inhibitor II | 2-(3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl)-1,5-naphthyridine | DTXSID80332295 | AKOS016009677 | Tox21_500541 | 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine | J-507645 | NSC756354 | NSC-756354 | SMR004702903 | BCP041
CAS number446859-33-2molecular formulaC17H13N5
molecular weight287.32 g/molExact mass≥98%
PSA67.400 Ųlogp2.200

numbering system

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physicochemical properties

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Safety information

pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany：
3

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