CAS number：1219168-18-9 molecular formula：C24H25N5O·2HCl
Dorsomorphin 2HCl是一种有效的，可逆的AMPK选择性抑制剂，Ki为109 nM，对一些结构相关的激酶，包括ZAPK， SYK， PKCθ， PKA和JAK3没有显著的抑制作用。同时抑制了BMP一型受体作用。A potent and selective AMPK inhibitor. Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits BMP type I receptor. A potent and selective AMPK inhibitor.
| Chinese alias | - | ||
| English alias | BML-275 | 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine hydrochloride (1:2) | Compound C dihydrochloride | BML275 dihydrochloride | BML 275 dihydrochloride | ||
| CAS number | 1219168-18-9 | molecular formula | C24H25N5O·2HCl |
| molecular weight | 472.41 g/mol | Exact mass | ≥98% |
| PSA | 55.600 Ų | logp | - |
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