compound introduction
Hygrolidin 是与杆状霉素密切相关的16元大环内酯，对苹果溃疡病的病原体具有活性。Hygrolidin 对SV40肿瘤细胞具有活性，并抑制实体肿瘤来源的细胞系（例如DLD-1人结肠癌细胞）的生长，其中G1和S期的细胞增多。Hygrolidin 可降低细胞周期蛋白依赖性激酶（cdk）4，细胞周期蛋白D和细胞周期蛋白B的水平，并增加细胞周期蛋白E和p21的水平。 Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against|Valsa ceratosperma|, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumour cells, and inhibits the growth of solid tumour-derived cell lines such as DLD-1 human colon cancer cells with increased cells in G1 and S phases. Hygrolidin decreases cyclin-dependent kinase (cdk) 4, cyclin D and cyclin B, and increases cyclin E and p21 levels.
