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Polyketomycin

CAS number:200625-47-4    molecular formula:C44H48O18

overview

compound introduction

聚酮霉素是四环醌糖苷,具有由链霉菌产色链霉菌产生的抗菌,抗肿瘤和抗疟原性。被称为蒽环类抗生素,对革兰氏阳性多药菌株(包括耐甲氧西林的金黄色葡萄球菌(MRSA))具有细胞毒性和生长抑制能力。在实验中显示对多种癌细胞具有有效的抗肿瘤活性。 Polyketomycin is a tetracyclic quinone glycoside with antibacterial, antitumor, and antimalarial ativity produced by Streptomyces diastatochromogenes. Known as an anthracycline antibiotic displaying cytotoxic and growth inhibitory ability against Gram-positive multi drug strains including methicillin-resistant Staphylococcus aureus (MRSA). Shown in experiments to have potent antitumor activity against multiple cancer cell lines.

Specs

Chinese alias-
English aliasCHEBI:66771 | DTXSID40942076 | (2R,3S,6S)-2-methyl-6-{[(1S,3E,4aS,12aR)-4a,6,12a-trihydroxy-3-(1-hydroxyethylidene)-9-methoxy-11-methyl-2,4,5,7,10-pentaoxo-1,2,3,4,4a,5,7,10,12,12a-decahydrotetracen-1-yl]oxy}tetrahydro-2H-pyran-3-yl 2,6-dideoxy-4-O-(2-hyd
CAS number200625-47-4molecular formulaC44H48O18
molecular weight864.84 g/molExact mass≥98%
PSA279.000 Ųlogp3.800

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